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What is the Easysweet Dengue IgG/IgM And NS1 Combo Rapid Test?

  Dengue virus-specific IgM and neutralizing antibodies usually appear by the end of the first week of illness. IgM levels are variable, but typically begin to be positive 4-5 days after symptom onset and persist for about 12 weeks after symptom onset, but may last longer.

  What is the Easysweet Dengue IgG/IgM And NS1 Combo Rapid Test?

  

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  Easysweet Dengue IgG/IgM And NS1 Combo Rapid Test is used for the qualitative detection of dengue virus IgM antibody.

  The Easysweet Dengue IgG/IgM And NS1 Combo Rapid Test is based on the use of anti-human IgM antibodies to capture human IgM antibodies on microtiter plates followed by the addition of dengue virus antigen. The antigens used in this assay are derived from the envelope proteins of four dengue virus serotypes (DENV-1-4).

  How and when should it be used during an infection?

  As the immune system fights the infection, IgM antibodies against the dengue virus become detectable starting 4-5 days after symptoms appear and are reliably detectable for about 12 weeks.

  A test combining nucleic acid amplification test (NAAT) and MAC-ELISA usually provides diagnostic results within the first 1-7 days of illness. Convalescent specimens are required for the diagnosis of dengue virus infection when both tests are negative on acute specimens.

  IgM antibody testing is not useful for dengue virus serotyping.

  Some IgM tests are available on plasma and whole blood, but these tests have not been extensively evaluated for these sample types.

  IgM Positive: Patients with positive IgM test results were classified as having presumptive recent dengue virus infection.

  Negative IgM:

  Patients with negative IgM results and absent or negative NAAT or NS1 results before day 8 of illness were considered undiagnosed cases. For these cases, a second sample should be obtained 7 days after symptom onset for additional serological testing.

  Patients with negative IgM results 7 days after symptom onset and absent or negative NAAT or NS1 (dengue virus antigen test) were classified as negative for recent infection.

  Patients whose IgM results changed from negative to positive were classified as having current dengue infection in paired samples (the first sample collected within the first 7 days of illness, and the second sample collected after resolution of symptoms).

  Results may be difficult to interpret due to cross-reactivity with other flaviviruses and possible nonspecific reactivity. Therefore, presumptive positive, inconclusive, and equivocal IgM antibody test results may be forwarded for confirmation with a plaque reduction neutralization test (PRNT).

  Easysweet Dengue IgG/IgM And NS1 Combo Rapid Test is also available as a laboratory developed test in public health and commercial clinical laboratories or as a diagnostic kit.

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